English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/88007
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Structural dynamics of picornaviral RdRP complexes. Implications for the design of antivirals

AuthorsVerdaguer, Núria ; Ferrer-Orta, Cristina ; Domingo, Esteban
KeywordsRibavirin
RNA-dependent RNA polymerase
Replication fidelity
Picornavirus
Issue Date2012
PublisherSpringer
CitationMacromolecular Crystallography: 183-193 (2012)
SeriesNATO Science for Peace and Security Series A: Chemistry and Biology 2012
AbstractGenome replication in picornavirus is catalyzed by a virally encoded RNA dependent RNA polymerase, termed 3D. These viruses also use a small protein primer, named VPg to initiate RNA replication. Polymerase 3D also catalyzes the covalent linkage of UMP to a N-terminal tyrosine on VPg. Seven different crystal structures of foot-and-mouth disease virus (FMDV) 3D catalytic complexes have enhanced our understanding of template and primer recognition, VPg uridylylation and rNTP binding and catalysis. In addition, the biochemical and structural analyses of six different FMDV 3D ribavirin resistant mutants provided evidences of three different mechanisms of resistance to this mutagenic nucleoside analogue. Such structural information is providing new insights into the fidelity of RNA replication, and for the design of antiviral compounds. © 2012 Springer Science+Business Media B.V.
URIhttp://hdl.handle.net/10261/88007
DOI10.1007/978-94-007-2530-0_17
Identifiersdoi: 10.1007/978-94-007-2530-0_17
isbn: 978-94-007-2529-4
Appears in Collections:(IBMB) Libros y partes de libros
(CBM) Libros y Partes de Libros
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.