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dc.contributor.author | Vizcaíno, Carolina | - |
dc.contributor.author | Mansilla, Sylvia | - |
dc.contributor.author | Méndez, Carmen | - |
dc.contributor.author | Salas, José A. | - |
dc.contributor.author | Portugal, José | - |
dc.date.accessioned | 2013-12-02T09:02:16Z | - |
dc.date.available | 2013-12-02T09:02:16Z | - |
dc.date.issued | 2012 | - |
dc.identifier | doi: 10.1016/j.bcp.2012.08.003 | - |
dc.identifier | issn: 0006-2952 | - |
dc.identifier | e-issn: 1873-2968 | - |
dc.identifier.citation | Biochemical Pharmacology 84(9): 1133-1142 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/87938 | - |
dc.description.abstract | The effects of mithramycin SK (MSK) and demycarosyl-3D-β-d- digitoxosyl-mithramycin SK (DIG-MSK; EC-8042), two novel analogs of the antitumor antibiotic mithramycin A, on gene transcription were examined in human HCT116 colon carcinoma cells by quantitative real-time PCR of 89 genes mainly involved in cell cycle control. Each one of the analogs down-regulated a different set of genes, while only five genes were down-regulated by both compounds. Moreover, other genes were significantly up-regulated, among them p21 WAF1/CDKN1A which is involved in halting cells at the G1 and G2/M checkpoints. These results are rationalized in terms of MSK or DIG-MSK competition with various transcription factors for binding to consensus C/G-rich tracts encompassed in gene promoters. Changes in cell cycle distribution and protein levels after treatment with every analog were consistent with changes observed in gene expression. © 2012 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | This work was supported by grant BFU2010-15518 from the Spanish Ministry of Science and Innovation, and the FEDER program of the European Community, and it was performed within the framework of the “Xarxa de Referencia en Biotecnologia” of the Generalitat de Catalunya. Carolina Vizcaíno is recipient of a JAE-Predoc2010 fellowship (CSIC), co-financed by the European Social Fund. | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.subject | Mithramycin SK | - |
dc.subject | EC-8042 | - |
dc.subject | Antitumor drugs | - |
dc.subject | Transcription factors | - |
dc.title | Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.bcp.2012.08.003 | - |
dc.date.updated | 2013-12-02T09:02:16Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
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