English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/87908
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 19 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Hox genes regulate the onset of Tbx5 expression in the forelimb

Autor Minguillón, Carolina
Palabras clave Limb development
Tbx5
Hox
Fecha de publicación 2012
EditorCompany of Biologists
Citación Development 139(17): 3180-3188 (2012)
ResumenTbx4 and Tbx5 are two closely related T-box genes that encode transcription factors expressed in the prospective hindlimb and forelimb territories, respectively, of all jawed vertebrates. Despite their striking limb type-restricted expression pattern, we have shown that these genes do not participate in the acquisition of limb type-specific morphologies. Instead, Tbx4 and Tbx5 play similar roles in the initiation of hindlimb and forelimb outgrowth, respectively. We hypothesized that different combinations of Hox proteins expressed in different rostral and caudal domains of the lateral plate mesoderm, where limb induction occurs, might be involved in regulating the limb type-restricted expression of Tbx4 and Tbx5 and in the later determination of limb type-specific morphologies. Here, we identify the minimal regulatory element sufficient for the earliest forelimb-restricted expression of the mouse Tbx5 gene and show that this sequence is Hox responsive. Our results support a mechanism in which Hox genes act upstream of Tbx5 to control the axial position of forelimb formation. © 2012. Published by The Company of Biologists Ltd.
URI http://hdl.handle.net/10261/87908
DOI10.1242/dev.084814
Identificadoresdoi: 10.1242/dev.084814
issn: 0950-1991
e-issn: 1477-9129
Aparece en las colecciones: (IBMB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.