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Age-Related Changes in Monochromatic Wave Aberrations of the Human Eye

AuthorsMcLellan, James S.; Marcos, Susana ; Burns, Stephen A.
KeywordsHuman eye
Optical aberrations
Optical quality
Modulation Transfer Function (MTF)
Wave aberrations
Aging effects
Issue DateMay-2001
PublisherAssociation for Research in Vision and Ophthalmology
Lippincott Williams & Wilkins
CitationInvestigative Ophthalmology & Visual Science 42(6): 1390-1395 (2001)
Abstract[Purpose] To investigate the relations between age and the optical aberrations of the whole eye. The eye’s optical quality, as measured by the modulation transfer function (MTF), degrades with age, but the MTF does not provide a means to assess the contributions of individual aberrations, such as coma, spherical aberration, and other higher order aberrations to changes in optical quality. The method used in this study provides measures of individual aberrations and overall optical quality.
[Methods] Wave aberrations in 38 subjects were measured psychophysically using a spatially resolved refractometer. Data were fit with Zernike polynomials up to the seventh order to provide estimates of 35 individual aberration terms. MTFs and root mean square (RMS) wavefront errors were calculated. Subjects ranged in age from 22.9 to 64.5 years, with spherical equivalent corrections ranging from +0.5 to -6.0 D.
[Results] Overall RMS wavefront error (excluding tilts, astigmatism, and defocus) was significantly positively correlated with age (r = 0.33, P = 0.042). RMS error for the highest order aberrations measured (fifth through seventh order) showed a strong positive correlation with age (r = 0.57, P = 0.0002). Image quality, as quantified by the MTF, also degraded with age.
[Conclusions] Wave aberrations of the eye increase with age. This increase is consistent with the loss of contrast sensitivity with age observed by other investigators.
Description6 pages, 7 figures.-- PMID: 11328756 [PubMed].-- Open Access full-text paper available at the publisher's site.
Publisher version (URL)http://www.iovs.org/cgi/content/abstract/42/6/1390
Appears in Collections:(CFMAC-IO) Artículos
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