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Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program

AuthorsEstarás, Conchi ; Akizu, Naiara; García, Alejandra; Beltrán, Sergi; Cruz, Xavier de la ; Martínez-Balbás, Marian
KeywordsEpigenetic regulation
JMJD3 (Kdm6b)
TGFβ pathway
Histone demethylation
Issue Date2012
PublisherCompany of Biologists
CitationDevelopment 139(15): 2681-2691 (2012)
AbstractNeural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFβ pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFβ-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3 is dependent on JMJD3 HDM activity. Overall, these findings indicate that JMJD3 function is required for the TGFβ developmental program to proceed.
Publisher version (URL)http://dx.doi.org/10.1242/dev.078345
Identifiersdoi: 10.1242/dev.078345
e-issn: 1477-9129
issn: 0950-1991
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