English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/87844
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Quantitative analysis of cellular metabolic dissipative, self-organized structures

AuthorsDe la Fuente, Ildefonso M.
Keywordsmetabolic dynamics
systems biology
quantitative biology
dissipative structures
metabolic self-organization
Issue Date2010
PublisherMultidisciplinary Digital Publishing Institute
CitationInternational Journal of Molecular Sciences 11: 3540- 3599 (2010)
AbstractOne of the most important goals of the postgenomic era is understanding the metabolic dynamic processes and the functional structures generated by them. Extensive studies during the last three decades have shown that the dissipative self-organization of the functional enzymatic associations, the catalytic reactions produced during the metabolite channeling, the microcompartmentalization of these metabolic processes and the emergence of dissipative networks are the fundamental elements of the dynamical organization of cell metabolism. Here we present an overview of how mathematical models can be used to address the properties of dissipative metabolic structures at different organizational levels, both for individual enzymatic associations and for enzymatic networks. Recent analyses performed with dissipative metabolic networks have shown that unicellular organisms display a singular global enzymatic structure common to all living cellular organisms, which seems to be an intrinsic property of the functional metabolism as a whole. Mathematical models firmly based on experiments and their corresponding computational approaches are needed to fully grasp the molecular mechanisms of metabolic dynamical processes. They are necessary to enable the quantitative and qualitative analysis of the cellular catalytic reactions and also to help comprehend the conditions under which the structural dynamical phenomena and biological rhythms arise. Understanding the molecular mechanisms responsible for the metabolic dissipative structures is crucial for unraveling the dynamics of cellular life. © 2010 by the authors; licensee MDPI, Basel, Switzerland.
URIhttp://hdl.handle.net/10261/87844
DOIhttp://dx.doi.org/10.3390/ijms11093540
Identifiersdoi: 10.3390/ijms11093540
issn: 1422-0067
Appears in Collections:(IPBLN) Artículos
Files in This Item:
File Description SizeFormat 
Quantitative.pdf871,76 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.