English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/87809
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 43 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation

Autor Colomina, Neus; Garí, Eloi; Gallego, Carme ; Aldea, Marti
Palabras clave Biological sciences
Cell biology
Fecha de publicación 2012
EditorNature Publishing Group
Citación Nature Communications 3: 1012 (2012)
ResumenBudding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain a critical size set by external conditions. However, arguing against deterministic models of cell size control, cell volume at Start displays great individual variability even under constant conditions. Here we show that cell size at Start is robustly set at a single-cell level by the volume growth rate in G1, which explains the observed variability. We find that this growth-rate-dependent sizer is intimately hardwired into the Start network and the Ydj1 chaperone is key for setting cell size as a function of the individual growth rate. Mathematical modelling and experimental data indicate that a growth-rate-dependent sizer is sufficient to ensure size homeostasis and, as a remarkable advantage over a rigid sizer mechanism, it reduces noise in G1 length and provides an immediate solution for size adaptation to external conditions at a population level. © 2012 Macmillan Publishers Limited. All rights reserved.
URI http://hdl.handle.net/10261/87809
DOI10.1038/ncomms2015
Identificadoresdoi: 10.1038/ncomms2015
e-issn: 2041-1723
Aparece en las colecciones: (IBMB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.