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Título

Characterization of the impact of alternative splicing on protein dynamics: The cases of glutathione S-transferase and ectodysplasin-A isoforms

Autor Barbany, Montserrat; Morata, Jordi; Meyer, Tim; Lois, Sergi; Orozco, Modesto; Cruz, Xavier de la
Palabras clave Allosterism
Protein isoforms
Protein structure
Protein disorder
Protein dynamics
Fecha de publicación 2012
EditorWiley-Blackwell
Citación Proteins 80(9): 2235-2249 (2012)
ResumenRecent studies have shown how alternative splicing (AS), the process by which eukaryotic genes express more than one product, affects protein sequence and structure. However, little information is available on the impact of AS on protein dynamics, a property fundamental for protein function. In this work, we have addressed this issue using molecular dynamics simulations of the isoforms of two model proteins: glutathione S-transferase and ectodysplasin-A. We have found that AS does not have a noticeable impact on global or local structure fluctuations. We have also found that, quite interestingly, AS has a significant effect on the coupling between key structural elements such as surface cavities. Our results provide the first atom-level view of the impact of AS on protein dynamics, as far as we know. They can contribute to refine our present view of the relationship between AS and protein disorder and, more importantly, they reveal how AS may modify structural dynamic couplings in proteins. © 2012 Wiley Periodicals, Inc.
URI http://hdl.handle.net/10261/87780
DOI10.1002/prot.24112
Identificadoresdoi: 10.1002/prot.24112
issn: 0887-3585
e-issn: 1097-0134
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