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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/87719
Título

Structural insights into transcription complexes

AutorBlanco, Alexandre G.; Coll, Miquel ; Folkers, Gert E.; Wilmanns, Matthias; Moras, Dino; Poterszman, Arnaud
Palabras claveTranscription factors
Multi-subunit complexes
Structural proteomics
Regulation of gene expression
Fecha de publicación2011
EditorElsevier
CitaciónJournal of Structural Biology 175(2): 135-146 (2011)
ResumenControl of transcription allows the regulation of cell activity in response to external stimuli and research in the field has greatly benefited from efforts in structural biology. In this review, based on specific examples from the European SPINE2-COMPLEXES initiative, we illustrate the impact of structural proteomics on our understanding of the molecular basis of gene expression. While most atomic structures were obtained by X-ray crystallography, the impact of solution NMR and cryo-electron microscopy is far from being negligible. Here, we summarize some highlights and illustrate the importance of specific technologies on the structural biology of protein-protein or protein/DNA transcription complexes: structure/function analysis of components the eukaryotic basal and activated transcription machinery with focus on the TFIID and TFIIH multi-subunit complexes as well as transcription regulators such as members of the nuclear hormone receptor families. We also discuss molecular aspects of promoter recognition and epigenetic control of gene expression. © 2011 Elsevier Inc.
URIhttp://hdl.handle.net/10261/87719
DOI10.1016/j.jsb.2011.04.015
Identificadoresdoi: 10.1016/j.jsb.2011.04.015
issn: 1047-8477
e-issn: 1095-8657
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