English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/87719
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Structural insights into transcription complexes

AuthorsBlanco, Alexandre G.; Coll, Miquel ; Folkers, Gert E.; Wilmanns, Matthias; Moras, Dino; Poterszman, Arnaud
KeywordsTranscription factors
Multi-subunit complexes
Structural proteomics
Regulation of gene expression
Issue Date2011
PublisherElsevier
CitationJournal of Structural Biology 175(2): 135-146 (2011)
AbstractControl of transcription allows the regulation of cell activity in response to external stimuli and research in the field has greatly benefited from efforts in structural biology. In this review, based on specific examples from the European SPINE2-COMPLEXES initiative, we illustrate the impact of structural proteomics on our understanding of the molecular basis of gene expression. While most atomic structures were obtained by X-ray crystallography, the impact of solution NMR and cryo-electron microscopy is far from being negligible. Here, we summarize some highlights and illustrate the importance of specific technologies on the structural biology of protein-protein or protein/DNA transcription complexes: structure/function analysis of components the eukaryotic basal and activated transcription machinery with focus on the TFIID and TFIIH multi-subunit complexes as well as transcription regulators such as members of the nuclear hormone receptor families. We also discuss molecular aspects of promoter recognition and epigenetic control of gene expression. © 2011 Elsevier Inc.
URIhttp://hdl.handle.net/10261/87719
DOIhttp://dx.doi.org/10.1016/j.jsb.2011.04.015
Identifiersdoi: 10.1016/j.jsb.2011.04.015
issn: 1047-8477
e-issn: 1095-8657
Appears in Collections:(IBMB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.