English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/87468
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
DC FieldValueLanguage
dc.contributor.authorVidossich, Pietro-
dc.contributor.authorAlfonso-Prieto, Mercedes-
dc.contributor.authorCarpena, Xavi-
dc.contributor.authorFita, Ignacio-
dc.contributor.authorLoewen, Peter C.-
dc.contributor.authorRovira, Carme-
dc.date.accessioned2013-11-25T12:19:46Z-
dc.date.available2013-11-25T12:19:46Z-
dc.date.issued2010-
dc.identifierdoi: 10.1016/j.abb.2010.04.021-
dc.identifierissn: 0003-9861-
dc.identifiere-issn: 1096-0384-
dc.identifier.citationArchives of Biochemistry and Biophysics 500(1): 37-44 (2010)-
dc.identifier.urihttp://hdl.handle.net/10261/87468-
dc.description.abstractThe enzymatic cycle of hydroperoxidases involves the resting Fe(III) state of the enzyme and the high-valent iron intermediates Compound I and Compound II. These states might be characterized by X-ray crystallography and the transition pathways between each state can be investigated using atomistic simulations. Here we review our recent work in the modeling of two key steps of the enzymatic reaction of hydroperoxidases: the formation of Cpd I in peroxidase and the reduction of Cpd I in catalase. It will be shown that small conformational motions of distal side residues (His in peroxidases and His/Asn in catalases), not,or only partially, revealed by the available X-ray structures, play an important role in the catalytic processes examined. © 2010 Elsevier Inc.-
dc.description.sponsorshipThe authors thank the Spanish Ministry of Science and Innovation (MICINN) (Grant FIS2008-03845) and the Generalitat de Catalunya (Grant 2009SGR-1309) for its financial assistance. -
dc.language.isoeng-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.titleThe dynamic role of distal side residues in heme hydroperoxidase catalysis. Interplay between X-ray crystallography and ab initio MD simulations-
dc.typeartículo-
dc.identifier.doi10.1016/j.abb.2010.04.021-
dc.date.updated2013-11-25T12:19:46Z-
dc.description.versionPeer Reviewed-
Appears in Collections:(IBMB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.