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Title

Stable ion complexes of vitamin A species (retinol) in solution as detected by mass spectrometry

AuthorsSánchez-Guijo, Alberto; Montero, Olimpio
Issue Date2010
PublisherWiley-Blackwell
CitationRapid Communications in Mass Spectrometry 24(8): 1161-1164 (2010)
AbstractMechanisms of retinol (ROL) transport in plasma alternative to that involving the Retinol-Binding Protein (RBP) have been hypothesized after RBP-knockout mice were shown to be viable and fertile. Accordingly, the possibility of a ROL fraction circulating free in plasma has been suggested. In this study, stable complex formation between ROL and the physiological relevant ions Na+, Li+, and K+ was investigated by using mass spectrometry and assessed in regard to the aforementioned alternative mechanism. The ROL-Na complex was found to be kinetically favoured with respect to the ROL-Li and ROL-K complexes. Fragmentation of the [ROL-Na]+ adduct rendered the carbocation [ROL+H-H2O]+ (m/z 269) and NaOH as neutral loss. In consonance with these results, it is hypothesized on the possibility of the complex [ROL-Na]+ being an alternative way of ROL transport to cells, as well as an intermediate in cis/trans isomerism. © 2010 John Wiley & Sons, Ltd.
URIhttp://hdl.handle.net/10261/87371
DOI10.1002/rcm.4497
Identifiersdoi: 10.1002/rcm.4497
issn: 0951-4198
e-issn: 1097-0231
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