English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/87368
Título

Synthesis and biological properties of new 5-nitroindazole derivatives

AutorArán, Vicente J. ; Ochoa, Carmen; Boiani, Lucía; Buccino, Pablo; Cerecetto, Hugo; Gerpe, Alejandra; González, Mercedes; Montero, David; Nogal, Juan José; Gómez-Barrio, Alicia; Azqueta, Amaya; López De Ceráin, Adela; Piro, Oscar E.; Castellano, Eduardo E.
Fecha de publicación2005
EditorPergamon Press
CitaciónBioorganic and Medicinal Chemistry 13: 3197- 3207 (2005)
ResumenA series of new 3-alkoxy- or 3-hydroxy-1-[ω-(dialkylamino)alkyl]-5- nitroindazoles have been synthesized and their trichomonacidal, antichagasic and antineoplastic properties studied. Five derivatives (5, 6, 8, 9 and 17) showed remarkable trichomonacidal activity against Trichomonas vaginalis at 10 μg/mL concentration. Three compounds (8, 10, 11) exhibited interesting antichagasic activity and these same compounds moderate antineoplastic activity against TK-10 and HT-29 cell lines. Unspecific cytotoxicity against macrophages has also been evaluated and only compounds 9, 10 and 11 resulted cytotoxic at the higher dose evaluated (100 μg/mL), loosing cytotoxicity at lower doses. QSAR studies have been carried out. X-ray crystallographic study of compound 8 has been performed. © 2005 Elsevier Ltd. All rights reserved.
URIhttp://hdl.handle.net/10261/87368
DOI10.1016/j.bmc.2005.02.043
Identificadoresdoi: 10.1016/j.bmc.2005.02.043
issn: 0968-0896
e-issn: 1464-3391
Aparece en las colecciones: (IQM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.