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ChIPCodis: Mining complex regulatory systems in yeast by concurrent enrichment analysis of Chip-on-chip data

AuthorsAbascal, Federico ; Carmona-Sáez, Pedro; Carazo, José M.; Pascual-Montano, Alberto
Issue Date12-Mar-2008
PublisherOxford University Press
CitationBioinformatics; 24(9):1208-1209 (2008)
AbstractMotivation: Eukaryotic genes are often regulated by multiple transcription factors (TFs). Depending on the interactions among different TFs the expression of a gene can be tuned to respond to diverse environmental conditions. Chip-on-chip experiments provide a snapshot of which TF are in vivo bound to which genes in a particular condition, and have been applied to characterize the regulatory code of yeast under several experimental settings. ChIPCodis mines this data to provide new insights about how the expression of a particular group of genes is regulated. For a given list of yeast genes ChIPCodis determines which combinations of TFs are significantly over-represented in a series of environmental conditions.
Description2 pages. -- Printed version published on May 2008. -- PMID: 18339638 [PubMed].
Publisher version (URL)http://dx.doi.org/10.1093/bioinformatics/btn094
Appears in Collections:(CNB) Artículos
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