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Título

ChIPCodis: Mining complex regulatory systems in yeast by concurrent enrichment analysis of Chip-on-chip data

Autor Abascal, Federico ; Carmona-Sáez, Pedro; Carazo, José M.; Pascual-Montano, Alberto
Fecha de publicación 12-mar-2008
EditorOxford University Press
Citación Bioinformatics; 24(9):1208-1209 (2008)
ResumenMotivation: Eukaryotic genes are often regulated by multiple transcription factors (TFs). Depending on the interactions among different TFs the expression of a gene can be tuned to respond to diverse environmental conditions. Chip-on-chip experiments provide a snapshot of which TF are in vivo bound to which genes in a particular condition, and have been applied to characterize the regulatory code of yeast under several experimental settings. ChIPCodis mines this data to provide new insights about how the expression of a particular group of genes is regulated. For a given list of yeast genes ChIPCodis determines which combinations of TFs are significantly over-represented in a series of environmental conditions.
Descripción 2 pages. -- Printed version published on May 2008. -- PMID: 18339638 [PubMed].
Versión del editorhttp://dx.doi.org/10.1093/bioinformatics/btn094
URI http://hdl.handle.net/10261/8684
DOI10.1093/bioinformatics/btn094
ISSN1367-4803
Aparece en las colecciones: (CNB) Artículos
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