English
español
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/8683
Share/Impact:
Statistics |
![]() ![]() ![]() |
|
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |||
|
Title: | SPACE: an algorithm to predict and quantify alternatively spliced isoforms using microarrays |
Authors: | Antón, Miguel A.; Gorostiaga, Dorleta; Guruceaga, Elizabeth; Segura, Víctor; Carmona-Sáez, Pedro; Pascual-Montano, Alberto; Pio, Rubén; Montuenga, Luis M.; Rubio, Angel ![]() |
Keywords: | Bioinformatics Molecular biology Genome studies |
Issue Date: | 29-Feb-2008 |
Publisher: | BioMed Central |
Citation: | Genome Biol. 9(2):R46 (2008) |
Abstract: | Exon and exon+junction microarrays are promising tools for studying alternative splicing. Current analytical tools applied to these arrays lack two relevant features: the ability to predict unknown spliced forms and the ability to quantify the concentration of known and unknown isoforms. SPACE is an algorithm that has been developed to (1) estimate the number of different transcripts expressed under several conditions, (2) predict the precursor mRNA splicing structure and (3) quantify the transcript concentrations including unknown forms. The results presented here show its robustness and accuracy for real and simulated data. |
Description: | 20 pages, 13 figures.-- Supplementary material available at: http://genomebiology.com/2008/9/2/R46/additional/ (Additional data file 1: 22 Figures. Additional data file 2: Matlab data files).-- PMCID: PMC2374713. |
Publisher version (URL): | http://dx.doi.org/10.1186/gb-2008-9-2-r46 |
URI: | http://hdl.handle.net/10261/8683 |
DOI: | http://dx.doi.org/10.1186/gb-2008-9-2-r46 |
ISSN: | 1465-6906 |
E-ISSN: | 1465-6914 |
Appears in Collections: | (CNB) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
SPACE.pdf | Article Final Version | 799,95 kB | Adobe PDF | ![]() View/Open |
Additional_file_1.pdf | Additional file 1 | 299,02 kB | Adobe PDF | ![]() View/Open |
Additional_file_2.zip | Additional file 2 | 21,56 kB | Unknown | View/Open |
Show full item record
Review this work
Review this work
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.