English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/8683
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


SPACE: an algorithm to predict and quantify alternatively spliced isoforms using microarrays

AuthorsAntón, Miguel A.; Gorostiaga, Dorleta; Guruceaga, Elizabeth; Segura, Víctor; Carmona-Sáez, Pedro; Pascual-Montano, Alberto; Pio, Rubén; Montuenga, Luis M.; Rubio, Angel
Molecular biology
Genome studies
Issue Date29-Feb-2008
PublisherBioMed Central
CitationGenome Biol. 9(2):R46 (2008)
AbstractExon and exon+junction microarrays are promising tools for studying alternative splicing. Current analytical tools applied to these arrays lack two relevant features: the ability to predict unknown spliced forms and the ability to quantify the concentration of known and unknown isoforms. SPACE is an algorithm that has been developed to (1) estimate the number of different transcripts expressed under several conditions, (2) predict the precursor mRNA splicing structure and (3) quantify the transcript concentrations including unknown forms. The results presented here show its robustness and accuracy for real and simulated data.
Description20 pages, 13 figures.-- Supplementary material available at: http://genomebiology.com/2008/9/2/R46/additional/ (Additional data file 1: 22 Figures. Additional data file 2: Matlab data files).-- PMCID: PMC2374713.
Publisher version (URL)http://dx.doi.org/10.1186/gb-2008-9-2-r46
Appears in Collections:(CNB) Artículos
Files in This Item:
File Description SizeFormat 
SPACE.pdfArticle Final Version799,95 kBAdobe PDFThumbnail
Additional_file_1.pdfAdditional file 1299,02 kBAdobe PDFThumbnail
Additional_file_2.zipAdditional file 221,56 kBUnknownView/Open
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.