Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/86809
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Synthetic cannabinoid quinones: Preparation, in vitro antiproliferative effects and in vivo prostate antitumor activity |
Autor: | Morales, Paula CSIC ORCID; Vara, Diana; Gómez-Cañas, María; Zúñiga, María C.; Olea-Azar, Claudio; Goya, Pilar CSIC ORCID; Fernández-Ruiz, Javier; Díaz-Laviada, Inés; Jagerovic, Nadine CSIC ORCID | Fecha de publicación: | 2013 | Editor: | Elsevier | Citación: | European Journal of Medicinal Chemistry 70: 111- 119 (2013) | Resumen: | Chromenopyrazolediones have been designed and synthesized as anticancer agents using the multi-biological target concept that involves quinone cytotoxicity and cannabinoid antitumor properties. In cell cytotoxicity assays, these chromenopyrazolediones have antiproliferative activity against human prostate cancer and hepatocellular carcinoma. It has been shown that the most potent, derivative 4 (PM49), inhibits prostate LNCaP cell viability (IC 50 = 15 μM) through a mechanism involving oxidative stress, PPARγ receptor and partially CB1 receptor. It acts on prostate cell growth by causing G0/G1 phase arrest and triggering apoptosis as assessed by flow cytometry measurements. In the in vivo treatment, compound 4 at 2 mg/kg, blocks the growth of LNCaP tumors and reduces the growth of PC-3 tumors generated in mice. These studies suggest that 4 is a good potential anticancer agent against hormone-sensitive prostate cancer. © 2013 Elsevier Masson SAS. All rights reserved. | Versión del editor: | https://doi.org/10.1016/j.ejmech.2013.09.043 | URI: | http://hdl.handle.net/10261/86809 | DOI: | 10.1016/j.ejmech.2013.09.043 | Identificadores: | doi: 10.1016/j.ejmech.2013.09.043 issn: 0223-5234 e-issn: 1768-3254 |
Aparece en las colecciones: | (IQM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
86809_Accepted.pdf | 1,09 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
38
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
37
checked on 26-feb-2024
Page view(s)
310
checked on 24-abr-2024
Download(s)
6
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons