English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/86724
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Ovine TRIM5α can restrict visna/maedi virus

AuthorsJáuregui, Paula ; Crespo, Helena ; Glaria, Idoia ; Luján, Lluís; Contreras, A.; Rosati, Sergio; Andrés, Damián F. de ; Amorena Zabalza, Beatriz ; Towers, G.J.; Reina, Ramsés
Issue DateJun-2012
PublisherAmerican Society for Microbiology
CitationJournal of Virology 86(17): 9504-9509 (2012)
AbstractThe restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections. © 2012, American Society for Microbiology.
Publisher version (URL)http://dx.doi.org/10.1128/JVI.00440-12
URIhttp://hdl.handle.net/10261/86724
DOI10.1128/JVI.00440-12
Identifiersdoi: 10.1128/JVI.00440-12
issn: 0022-538X
e-issn: 1098-5514
Appears in Collections:(IDAB) Artículos
Files in This Item:
File Description SizeFormat 
Ovine TRIM5α_Jauregui.pdf426,98 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.