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Título

Memory in viral quasispecies

Autor Ruiz-Jarabo, Carmen M.; Arias, Armando; Baranowski, Eric; Escarmís, Cristina; Domingo, Esteban
Palabras clave Viral quasispecies
Fecha de publicación 2000
EditorAmerican Society for Microbiology
Citación Journal of Virology, 2000, p. 3543-3547, Vol. 74, No. 8
ResumenBiological adaptive systems share some common features: variation among their constituent elements and continuity of core information. Some of them, such as the immune system, are endowed with memory of past events. In this study we provide direct evidence that evolving viral quasispecies possess a molecular memory in the form of minority components that populate their mutant spectra. The experiments have involved foot-and-mouth disease virus populations with known evolutionary histories. The composition and behavior of the viral population in response to a selective constraint were influenced by past evolutionary history in a way that could not be predicted from examination of consensus nucleotide sequences of the viral populations. The molecular memory of the viral quasispecies influenced both the nature and the intensity of the response of the virus to a selective constraint
Versión del editorhttp://jvi.asm.org/cgi/content/full/74/8/3543
URI http://hdl.handle.net/10261/8547
ISSN0022-538X (print)
1098-5514 (online)
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