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Adrenomedullin protects from experimental arthritis by down-regulating inflammation and Th1 response and inducing regulatory T cells

AuthorsGonzález-Rey, Elena; Chorny, Alejo; O'Valle, Francisco; Delgado, M.
Issue Date2007
PublisherAmerican Society for Investigative Pathology
CitationAmerican Journal of Pathology 170: 263- 271 (2007)
AbstractRheumatoid arthritis is a chronic autoimmune disease of unknown etiology characterized by chronic inflammation in the joints and subsequent destruction of the cartilage and bone. The present study proposes a new strategy for the treatment of arthritis: the administration of the immunomodulatory neuropeptide adrenomedullin. Treatment with adrenomedullin significantly reduced incidence and severity of collagen-induced arthritis, an experimental model of rheumatoid arthritis, completely abrogating joint swelling and destruction of cartilage and bone. The therapeutic effect of adrenomedullin was associated with a striking reduction of the two deleterious components of the disease, ie, the Th1-driven autoimmune and inflammatory responses. Adrenomedullin also induced the generation and/or activation of efficient CD4+CD25+ regulatory T cells in arthritis with capacity to suppress autoreactive response and restore immune tolerance, which could play a pivotal role in the therapeutic effect of adrenomedullin on experimental arthritis contributing to the restoration of immune tolerance. Copyright © American Society for Investigative Pathology.
Identifiersdoi: 10.2353/ajpath.2007.060596
issn: 0002-9440
Appears in Collections:(IPBLN) Artículos
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