Pre-T cell receptor (PRE-TCR) and the characterization and regulation of the expression and function thereof during the development of T cells in humans

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Title:	Pre-T cell receptor (PRE-TCR) and the characterization and regulation of the expression and function thereof during the development of T cells in humans
Authors:	Toribio, María Luisa ; Carrillo, Graciela; Rodríguez, Almudena; García de Yébenes, Virginia; Rodríguez, Yolanda
Keywords:	Human T lymphocytes
Issue Date:	27-Feb-2003
Citation:	WO 2003/016355 A1
Abstract:	The invention relates to technical tools that are used to identify and select subspecies of pre-T lymphocytes using the pre-T cell receptor (pTα). Moreover, said invention relates to methods of regulating the expression and function of said receptor during the development of human T lymphocytes. In one particular embodiment, the invention relates to monoclonal antibody K5G3 which recognises the pTαa isoform in a specific manner, thereby enabling the expression of the pTα chain on the cellular surface to be analysed for the first time
Description:	Filing Date: 2002-08-01 -- Priority Data ES P200101903 (2001-08-14)
URI:	http://hdl.handle.net/10261/8495
Appears in Collections:	(CBM) Patentes

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