English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/8436
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selection

Autor Borrego, Belén ; Novella, Isabel S.; Giralt, Ernest; Andreu, David; Domingo, Esteban
Palabras clave Foot-and-mouth disease virus
Fecha de publicación 1993
EditorAmerican Society for Microbiology
Citación J Virol. 1993; 67(10): 6071-6079
ResumenAntigenic variants of foot-and-mouth disease virus (FMDV) were generated and frequently became dominant in clonal populations of FMDV (clone C-S8c1) grown in the absence of anti-FMDV antibodies. We have now passaged eight samples of the same FMDV clone in the presence of a limited amount of neutralizing polyclonal antibodies directed to the major antigenic site A of capsid protein VP1. Complex populations of variants showing increased resistance to polyclonal sera and to site A-specific monoclonal antibodies were selected. Some populations exhibited marked decreases in viral fitness. Multiple amino acid replacements within site A--and also elsewhere in VP1--accumulated upon passage of the virus in either the absence or the presence of neutralizing antibodies. However, antigenically critical replacements at one position in site A occurred repeatedly in FMDV passaged under antibody selection, but they were never observed in many passages carried out either in the absence of antiviral antibodies or in the presence of an irrelevant antiviral serum. Thus, even though antigenic variation of FMDV can occur in the absence or presence of immune selection, critical replacements which lead to important changes in antigenic specificity were observed only as a result of selection by neutralizing antibodies
Versión del editorhttp://jvi.asm.org/cgi/content/abstract/67/10/6071
URI http://hdl.handle.net/10261/8436
ISSN0022-538X (print)
1098-5514 (online)
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
BBorrego_JVirol_6071.pdf1,79 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.