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dc.contributor.authorGambra, Enrique-
dc.contributor.authorOrtiz, Sergio-
dc.contributor.authorPérez Merino, Pablo-
dc.contributor.authorGora, Michalina-
dc.contributor.authorWojtkowski, Maciej-
dc.contributor.authorMarcos, Susana-
dc.identifierdoi: 10.1364/BOE.4.001595-
dc.identifierissn: 2156-7085-
dc.identifier.citationBiomedical Optics Express 4(9): 1595-1609 (2013)-
dc.description.abstractCustom high-resolution high-speed anterior segment spectral domain Optical Coherence Tomography (OCT) provided with automatic quantification and distortion correction algorithms was used to characterize three-dimensionally (3-D) the human crystalline lens in vivo in four subjects, for accommodative demands between 0 to 6 D in 1 D steps. Anterior and posterior lens radii of curvature decreased with accommodative demand at rates of 0.73 and 0.20 mm/D, resulting in an increase of the estimated optical power of the eye of 0.62 D per diopter of accommodative demand. Dynamic fluctuations in crystalline lens radii of curvature, anterior chamber depth and lens thickness were also estimated from dynamic 2-D OCT images (14 Hz), acquired during 5-s of steady fixation, for different accommodative demands. Estimates of the eye power from dynamical geometrical measurements revealed an increase of the fluctuations of the accommodative response from 0.07 D to 0.47 D between 0 and 6 D (0.044 D per D of accommodative demand). A sensitivity analysis showed that the fluctuations of accommodation were driven by dynamic changes in the lens surfaces, particularly in the posterior lens surface. © 2013 Optical Society of America.-
dc.description.sponsorshipThe authors acknowledge funding from Predoctoral fellowship CSIC-I3P2006 to EG; FNP Ventures Program co-financed by the EU Funds to MG; EURYI-01/2008-PL (EURHORCs) to MW; MICINN FIS2011-02065 to SM. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Program (FP/2007-2013) / ERC Grant Agreement n. [294099] to SM. The authors acknowledge technical hardware and software support of Ireneusz Grulkowski and Maciej Szkulmowski from NCU Toruń.-
dc.publisherOptical Society of America-
dc.titleStatic and dynamic crystalline lens accommodation evaluated using quantitative 3-D OCT-
dc.description.versionPeer Reviewed-
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