English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/8390
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Modulation of p53 cellular function and cell death by African Swine Fever Virus

AuthorsGranja, Aitor G. ; Nogal París, María Luisa ; Hurtado, Carolina ; Salas, José ; Salas, María Luisa; Carrascosa, Ángel L.; Revilla Novella, Yolanda
KeywordsAfrican swine fever virus
Issue Date2004
PublisherAmerican Society for Microbiology
CitationJournal of Virology, 2004, p. 7165-7174, Vol. 78, No. 13
AbstractModulation of the activity of tumor suppressor p53 is a key event in the replication of many viruses. We have studied the function of p53 in African swine fever virus (ASFV) infection by determining the expression and activity of this transcription factor in infected cells. p53 levels are increased at early times of infection and are maintained throughout the infectious cycle. The protein is transcriptionally active, stabilized by phosphorylation, and localized in the nucleus. p53 induces the expression of p21 and Mdm2. Strikingly, these two proteins are located at the cytoplasmic virus factories. The retention of Mdm2 at the factory may represent a viral mechanism to prevent p53 inactivation by the protein. The expression of apoptotic proteins, such as Bax or active caspase-3, is also increased following ASFV infection, although the increase in caspase-3 does not appear to be, at least exclusively, p53 dependent. Bax probably plays a role in the induction of apoptosis in the infected cells, as suggested by the release of cytochrome c from the mitochondria. The significance of p21 induction and localization is discussed in relation to the shutoff of cellular DNA synthesis that is observed in ASFV-infected cells.
Publisher version (URL)http://dx.doi.org/10.1128/JVI.78.13.7165-7174.2004
ISBN1098-5514 (online)
ISSN0022-538X (print)
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
AGGranja_JVirol_7165.pdf4,06 MBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.