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Time-course regulation of quercetin on cell survival/ proliferation pathways in human hepatoma cells

AuthorsGranado-Serrano, Ana B.; Martín, M. Angeles; Bravo, Laura ; Goya, Luis ; Ramos, Sonia
PI 3-kinase pathway
HepG2 cells
Issue Date2008
CitationMolecular Nutrition and Food Research 52(4): 457-464 (2008)
AbstractQuercetin, a dietary flavonoid, has been shown to possess anticarcinogenic properties, but the precise molecular mechanisms of action are not thoroughly elucidated. This study was aimed at investigating the time-course regulation effect of quercetin on survival/proliferation pathways in a human hepatoma cell line (HepG2). Quercetin induced a significant time-dependent inactivation of the major survival signaling proteins, i. e., phosphatidylinositol 3-kinase (PI 3-kinase)/protein kinase B (AKT), extracellular regulated kinase (ERK), protein kinase C-α (PKC-α), in concert with a time-dependent activation of key death-related signals: c-jun amino-terminal kinase (JNK) and PKC-δ. These data suggest that quercetin exerts a tight regulation of survival/proliferation pathways that requires the integration of different signals and persists over time, being the balance of these regulatory signals what determines the fate of HepG2 cells. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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