Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/83241
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Rodríguez-Hernández, Irene | - |
dc.contributor.author | Vázquez-Cedeira, Marta | - |
dc.contributor.author | Santos-Briz, Ángel | - |
dc.contributor.author | García, Juan L. | - |
dc.contributor.author | Fernández, Isabel F. | - |
dc.contributor.author | Gómez-Moreta, Juan A. | - |
dc.contributor.author | Martin-Vallejo, Javier | - |
dc.contributor.author | González-Sarmiento, Rogelio | - |
dc.contributor.author | Lazo, Pedro A. | - |
dc.date.accessioned | 2013-10-04T06:44:29Z | - |
dc.date.available | 2013-10-04T06:44:29Z | - |
dc.date.issued | 2013-10-01 | - |
dc.identifier | http://dx.doi.org/10.1186/1472-6890-13-23 | - |
dc.identifier.citation | BMC Clinical Pathology. 2013 Oct 01;13(1):23 | - |
dc.identifier.uri | http://hdl.handle.net/10261/83241 | - |
dc.description.abstract | Abstract Background Malignant astrocytomas are the most common primary brain tumors and one of the most lethal among human cancers despite optimal treatment. Therefore, the characterization of molecular alterations underlying the aggressive behavior of these tumors and the identification of new markers are thus an important step towards a better patient stratification and management. Methods and results VRK1 and VRK2 (Vaccinia-related kinase-1, -2) expression, as well as proliferation markers, were determined in a tissue microarray containing 105 primary astrocytoma biopsies. Kaplan Meier and Cox models were used to find clinical and/or molecular parameters related to overall survival. The effects of VRK protein levels on proliferation were determined in astrocytoma cell lines. High levels of both protein kinases, VRK1 or VRK2, correlated with proliferation markers, p63 or ki67. There was no correlation with p53, reflecting the disruption of the VRK-p53-DRAM autoregulatory loop as a consequence of p53 mutations. High VRK2 protein levels identified a subgroup of astrocytomas that had a significant improvement in survival. The potential effect of VRK2 was studied by analyzing the growth characteristics of astrocytoma cell lines with different EGFR/VRK2 protein ratios. Conclusion High levels of VRK2 resulted in a lower growth rate suggesting these cells are more indolent. In high-grade astrocytomas, VRK2 expression constitutes a good prognostic marker for patient survival. | - |
dc.description.sponsorship | M. V-C and I. R-H. were supported by fellowships from JAE/CSIC/Fondo Social Europeo and Junta de Castilla y León [Orden EDU/330/2008] respectively. This work was funded by grants from Ministerio de Educación, Ciencia e Innovación [SAF2010-14935], Junta de Castilla y León [CSI-006A11-2], and Kutxa-Fundación INBIOMED to P.A.L; and from Fondo de Investigación Sanitaria [FIS PI 10/00219] to R.G-S. The funders played no role in the design, execution or interpretation of this work. | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis | - |
dc.type | artículo | - |
dc.date.updated | 2013-10-04T06:44:29Z | - |
dc.description.version | Peer Reviewed | - |
dc.rights.holder | Irene Rodríguez-Hernández et al.; licensee BioMed Central Ltd. | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
1472-6890-13-23.xml | 85,83 kB | XML | Visualizar/Abrir | |
1472-6890-13-23-S5.PDF | 69,42 kB | Adobe PDF | Visualizar/Abrir | |
1472-6890-13-23-S4.PDF | 2,14 MB | Adobe PDF | Visualizar/Abrir | |
1472-6890-13-23-S1.PDF | 69,4 kB | Adobe PDF | Visualizar/Abrir | |
1472-6890-13-23-S3.PDF | 79,56 kB | Adobe PDF | Visualizar/Abrir | |
1472-6890-13-23.pdf | 1,05 MB | Adobe PDF | Visualizar/Abrir | |
1472-6890-13-23-S2.PDF | 131,23 kB | Adobe PDF | Visualizar/Abrir | |
1472-6890-13-23-S6.PDF | 326,29 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
323
checked on 18-abr-2024
Download(s)
863
checked on 18-abr-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.