English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/83241
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis

AuthorsRodríguez-Hernández, Irene; Vázquez-Cedeira, Marta ; Santos-Briz, Ángel; García, Juan L. ; Fernández, Isabel F. ; Gómez-Moreta, Juan A.; Martin-Vallejo, Javier; González-Sarmiento, Rogelio ; Lazo, Pedro A.
Issue Date1-Oct-2013
PublisherBioMed Central
CitationBMC Clinical Pathology. 2013 Oct 01;13(1):23
AbstractAbstract Background Malignant astrocytomas are the most common primary brain tumors and one of the most lethal among human cancers despite optimal treatment. Therefore, the characterization of molecular alterations underlying the aggressive behavior of these tumors and the identification of new markers are thus an important step towards a better patient stratification and management. Methods and results VRK1 and VRK2 (Vaccinia-related kinase-1, -2) expression, as well as proliferation markers, were determined in a tissue microarray containing 105 primary astrocytoma biopsies. Kaplan Meier and Cox models were used to find clinical and/or molecular parameters related to overall survival. The effects of VRK protein levels on proliferation were determined in astrocytoma cell lines. High levels of both protein kinases, VRK1 or VRK2, correlated with proliferation markers, p63 or ki67. There was no correlation with p53, reflecting the disruption of the VRK-p53-DRAM autoregulatory loop as a consequence of p53 mutations. High VRK2 protein levels identified a subgroup of astrocytomas that had a significant improvement in survival. The potential effect of VRK2 was studied by analyzing the growth characteristics of astrocytoma cell lines with different EGFR/VRK2 protein ratios. Conclusion High levels of VRK2 resulted in a lower growth rate suggesting these cells are more indolent. In high-grade astrocytomas, VRK2 expression constitutes a good prognostic marker for patient survival.
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
1472-6890-13-23.xml85,83 kBXMLView/Open
1472-6890-13-23-S5.PDF69,42 kBAdobe PDFThumbnail
1472-6890-13-23-S4.PDF2,14 MBAdobe PDFThumbnail
1472-6890-13-23-S1.PDF69,4 kBAdobe PDFThumbnail
1472-6890-13-23-S3.PDF79,56 kBAdobe PDFThumbnail
1472-6890-13-23.pdf1,05 MBAdobe PDFThumbnail
1472-6890-13-23-S2.PDF131,23 kBAdobe PDFThumbnail
1472-6890-13-23-S6.PDF326,29 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.