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dc.contributor.authorServili, Arianna-
dc.contributor.authorPage, Y. L.-
dc.contributor.authorLeprince, Jérôme-
dc.contributor.authorCaraty, Alain-
dc.contributor.authorEscobar, Sebastián-
dc.contributor.authorParhar, Ishwar S.-
dc.contributor.authorSeong, Jae Yong-
dc.contributor.authorVaudry, Hubert-
dc.contributor.authorKah, Olivier-
dc.date.accessioned2013-09-27T10:18:23Z-
dc.date.available2013-09-27T10:18:23Z-
dc.date.issued2011-
dc.identifier.citation9th International Symposium on Reproductive Physiology of Fish (2011)-
dc.identifier.urihttp://hdl.handle.net/10261/82944-
dc.descriptionPoster presentado en el 9th International Symposium on Reproductive Physiology of Fish celebrado en Cochin (India) del 9 al 14 de agosto de 2011-
dc.description.abstractBefore kisspeptins became new players in the field of reproductive biology, GnRH was acknowledged in all vertebrates as the major initiator of the hormonal cascade modulating the reproductive axis. Originally identified as a metastasis suppressor in mammals [1], the KISS1 gene produces several peptides named kisspeptins (kisspeptin -54, 14, 13, 10), which activate the KISS1 receptor (GPR54 or KISSR) previously known as an orphan receptor [2]. Recent phylogenetical analyses provided evidence that the number of kiss genes and kiss receptors varies from one class of vertebrate to the other. According to these studies [3] modern mammals have only one KISS gene, monotrems have two, birds would have none, reptiles have one, amphibians have three and fishes have two KISS genes. Similarly, the number of genes encoding GPR54 receptors (or Kissr) also varies from one class to the other. With the aim to enlarge our knowledge on organization and potential functions of Kiss systems in relation to GPR54 receptors in nonmammalian species, so far very poorly investigated, we have focused our interest on the elucidation of these systems in zebrafish, taken as model of study. Zebrafish have two kiss genes, kiss1 and kiss2 and two kiss receptors (GPR54), kiss1r and kiss2r. Conclusion: In addition of providing a successful strategy to develop antibodies to kisspeptins, this study provides for the first time detailed information on the organization of two separate kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of a vertebrate (see Figure 1 for a schematic representation). These data will be discussed in relation with steroids, melatonin and leptin signaling.-
dc.language.isoeng-
dc.publisherMadras Christian College-
dc.rightsclosedAccess-
dc.titleNeuroanatomical characterization of two independent kisspeptin systems derived from evolutionary-ancient kiss genes in the brain of zebrafish-
dc.typepóster de congreso-
dc.date.updated2013-09-27T10:18:24Z-
dc.description.versionPeer Reviewed-
Appears in Collections:(IATS) Comunicaciones congresos
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