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Kisspeptin/GPR54 expression in the brain of the European sea bass

AuthorsEscobar, Sebastián ; Espigares, F. ; Felip, Alicia ; Zanuy, Silvia ; Giueguen, Marie-Madeleine; Carrillo, Manuel ; Kah, Olivier; Servili, Arianna
Issue Date2011
Citation7th International Symposium on Fish Endocrinology (2012)
AbstractKisspeptins are key players in the neuroendocrine control of puberty and reproduction. Kiss genes, as kiss receptor genes, are present in vertebrates and derived from an ancestral gene that underwent gene duplication followed by gene losses. In most fish two kiss genes (kiss1 and kiss2) and two kiss receptor genes (kiss1r and kiss2r) are identified but the organization and functions of these systems are still poorly understood. In order to know whether both kiss genes are involved in the neuroendocrine control of reproduction in fish we studied Kisspeptin/GPR54 expression in the European sea bass (Dicentrarchus labrax), a Perciform fish. We also investigated whether Kiss neurons have any special link with the GnRH neurons and express estrogen receptors. Finally, the nature of the cells expressing kiss2r was studied using combination of in situ hybridization and immunohistochemistry. The main kiss1 expression site is the habenula, whereas kiss2 mRNA is mostly seen at the lateral recess. No sexual dimorphism is observed but an additional kiss1 expressing cells population is reported into the mediobasal hypothalamus during the spawning period. A few kiss2 cells of the preoptic region could make synaptic contact with the hypophysiotrophic GnRH neurons. The kiss population sensible to estrogens is in the ventral hypothalamus and corresponds to a kiss1 cell population. Our findings suggest that both kiss1 and kiss2 genes in sea bass would be likely to participate in the regulation of reproduction.
DescriptionPoster presentado en el 7th International Symposium on Fish Endocrinology celebrado en Buenos Aires del 3 al 6 de septiembre de 2012
Appears in Collections:(IATS) Comunicaciones congresos
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