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Título

Preextinction viral RNA can interfere with infectivity

Autor González-López, Claudia; Arias, Armando; Pariente, Nonia; Gómez-Mariano, Gema; Domingo, Esteban
Palabras clave Foot-and-mouth disease virus
RNA viral diseases
Fecha de publicación 2004
EditorAmerican Society for Microbiology
Citación Journal of Virology, 2004, p. 3319-3324, Vol. 78, No. 7
ResumenWhen the error rate during the copying of genetic material exceeds a threshold value, the genetic information cannot be maintained. This concept is the basis of a new antiviral strategy termed lethal mutagenesis or virus entry into error catastrophe. Critical for its success is preventing survival of residual infectious virus or virus mutants that escape the transition into error catastrophe. Here we document that mutated, preextinction foot-and-mouth disease virus (FMDV) RNA can interfere with and delay viral production up to 30 h when cotransfected in BHK-21 cells with standard RNA. Interference depended on the physical integrity of preextinction RNA and was not observed with unrelated RNAs or with nonmutated, defective FMDV RNA. These results suggest that this type of interference requires large size, preextinction FMDV RNA and is mediated neither by small interfering RNAs nor by RNAs that can compete with infectious RNA for host cell factors. A model based on the aberrant expression of mutated RNA as it is expected to occur in the initial stages of the transition into error catastrophe is proposed. Interference mediated by preextinction RNA indicates an advantage of mutagenesis versus inhibition in preventing the survival of virus escape mutants during antiviral treatments
Versión del editorhttp://dx.doi.org/10.1128/JVI.78.7.3319-3324.2004
URI http://hdl.handle.net/10261/8281
DOI10.1128/JVI.78.7.3319-3324.2004
ISSN0022-538X (print)
1098-5514 (online)
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