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Title

Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants

AuthorsSánchez, María B.; Hernández, Alvaro; Rodríguez-Martínez, José-Manuel; Martínez-Martínez, Luis; Martínez, José L.
KeywordsStenotrophomonas maltophilia
Qnr determinants
Predicting antibiotic resistance
Quinolone
Issue Date16-Sep-2008
PublisherBioMed Central
CitationBMC Microbiology 2008, 8:148
AbstractBackground Predicting antibiotic resistance before it emerges at clinical settings constitutes a novel approach for preventing and fighting resistance of bacterial pathogens. To analyse the possibility that novel plasmid-encoded quinolone resistance determinants (Qnr) can emerge and disseminate among bacterial pathogens, we searched the presence of those elements in nearly 1000 bacterial genomes and metagenomes. Results We have found a number of novel potential qnr genes in the chromosomes of aquatic bacteria and in metagenomes from marine organisms. Functional studies of the Stenotrophomonas maltophilia Smqnr gene show that plasmid-encoded SmQnr confers quinolone resistance upon its expression in a heterologous host. Conclusion Altogether, the data presented in our work support the notion that predictive studies on antibiotic resistance are feasible, using currently available information on bacterial genomes and with the aid of bioinformatic and functional tools. Our results confirm that aquatic bacteria can be the origin of plasmid-encoded Qnr, and highlight the potential role of S. maltophilia as a source of novel Qnr determinants.
DescriptionAdditional files: Microsoft excel document containing the descriptions of the genes shown in Figure 2.
Publisher version (URL)http://dx.doi.org/10.1186/1471-2180-8-148
URIhttp://hdl.handle.net/10261/8267
DOI10.1186/1471-2180-8-148
ISSN1471-2180
Appears in Collections:(CNB) Artículos
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