English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/8247
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Tufted Is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila

AuthorsVilla-Cuesta, Eugenia; Navascués, Joaquín de ; Ruiz-Gómez, Mar ; Díez del Corral, Ruth ; Domínguez, María; Celis, José F. de ; Modolell, Juan
Issue Date2003
PublisherGenetics Society of America
CitationGenetics, Vol. 163, 1403-1412, 2003
AbstractThe Tufted1 (Tft1) dominant mutation promotes the generation of ectopic bristles (macrochaetae) in the dorsal mesothorax of Drosophila. Here we show that Tft1 corresponds to a gain-of-function allele of the proneural gene amos that is associated with a chromosomal aberration at 36F–37A. This causes ectopic expression of amos in large domains of the lateral-dorsal embryonic ectoderm, which results in supernumerary neurons of the PNS, and in the notum region of the third instar imaginal wing, which gives rise to the mesothoracic extra bristles. Revertants of Tft1, which lack ectopic neurons and bristles, do not show ectopic expression of amos. One revertant is a loss-of-function allele of amos and has a recessive phenotype in the embryonic PNS. Our results suggest that both normal and ectopic Tft1 bristles are generated following similar rules, and both are subjected to Notch-mediated lateral inhibition. The ability of Tft1 bristles to appear close together may be due to amos having a stronger proneural capacity than that of other proneural genes like asense and scute. This ability might be related to the wild-type function of amos in promoting development of large clusters of closely spaced olfactory sensilla
Publisher version (URL)http://www.genetics.org/cgi/content/abstract/163/4/1403
Appears in Collections:(CBM) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.