Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/82183
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

To binge or not to binge: Binge drinking disrupts glucose homeostasis by impairing hypothalamic but not liver insulin signaling

AutorGarcía-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCID
Fecha de publicación2013
EditorWiley-Blackwell
CitaciónHepatology 57(6): 2535-2538 (2013)
ResumenIndividuals with a history of binge drinking have an increased risk of developing the metabolic syndrome and type 2 diabetes. Whether binge drinking impairs glucose homeostasis and insulin action is unknown. To test this, we treated Sprague-Dawley rats daily with alcohol (3 g/kg) for three consecutive days to simulate human binge drinking and found that these rats developed and exhibited insulin resistance even after blood alcohol concentrations had become undetectable. The animals were resistant to insulin for up to 54 hours after the last dose of ethanol, chiefly a result of impaired hepatic and adipose tissue insulin action. Because insulin regulates hepatic glucose production and white adipose tissue lipolysis, in part through signaling in the central nervous system, we tested whether binge drinking impaired brain control of nutrient partitioning. Rats that had consumed alcohol exhibited impaired hypothalamic insulin action, defined as the ability of insulin infused into the mediobasal hypothalamus to suppress hepatic glucose production and white adipose tissue lipolysis. Insulin signaling in the hypothalamus, as assessed by insulin receptor and AKT phosphorylation, decreased after binge drinking. Quantitative polymerase chain reaction showed increased hypothalamic inflammation and expression of protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling. Intracerebroventricular infusion of CPT-157633, a small-molecule inhibitor of PTP1B, prevented binge drinking-induced glucose intolerance. These results show that, in rats, binge drinking induces systemic insulin resistance by impairing hypothalamic insulin action and that this effect can be prevented by inhibition of brain PTP1B. © 2013 by the American Association for the Study of Liver Diseases.
DescripciónComment on: "Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action".
Versión del editorhttp://dx.doi.org/10.1002/hep.26423
URIhttp://hdl.handle.net/10261/82183
DOI10.1002/hep.26423
Identificadoresdoi: 10.1002/hep.26423
issn: 0270-9139
e-issn: 1527-3350
Aparece en las colecciones: (IIBB) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

1
checked on 27-mar-2024

WEB OF SCIENCETM
Citations

1
checked on 29-feb-2024

Page view(s)

348
checked on 28-mar-2024

Download(s)

114
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.