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dc.contributor.authorFrançois, K. O.-
dc.contributor.authorPannecouque, C.-
dc.contributor.authorAuwerx, Johan-
dc.contributor.authorLozano, Virginia-
dc.contributor.authorPeréz-Pérez, María-Jesús-
dc.contributor.authorSchols, Dominique-
dc.contributor.authorBalzarini, Jan-
dc.date.issued2009-
dc.identifierdoi: 10.1128/AAC.00811-09-
dc.identifierissn: 0066-4804-
dc.identifiere-issn: 1098-6596-
dc.identifier.citationAntimicrobial Agents and Chemotherapy 53: 4852- 4859 (2009)-
dc.identifier.urihttp://hdl.handle.net/10261/82154-
dc.description.abstractAlcian Blue (AB), a phthalocyanine derivative, is able to prevent infection by a wide spectrum of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains in various cell types [T cells, (co)receptor-transfected cells, and peripheral blood mononuclear cells]. With the exception of herpes simplex virus, AB is inactive against a broad variety of other (DNA and RNA) viruses. Time-of-addition studies show that AB prevents HIV-1 infection at the virus entry stage, exactly at the same time as carbohydrate-binding agents do. AB also efficiently prevents fusion between persistently HIV-1-infected HUT-78 cells and uninfected (CD4+) lymphocytes, DC-SIGN-directed HIV-1 capture, and subsequent transmission to uninfected (CD4+) T lymphocytes. Prolonged passaging of HIV-1 at dose-escalating concentrations of AB resulted in the selection of mutant virus strains in which several N-glycans of the HIV-1 gp120 envelope were deleted and in which positively charged amino acid mutations in both gp120 and gp41 appeared. A mutant virus strain in which four N-glycans were deleted showed a 10-fold decrease in sensitivity to the inhibitory effect of AB. These data suggest that AB is likely endowed with carbohydrate-binding properties and can be considered an important lead compound in the development of novel synthetic nonpeptidic antiviral drugs targeting the glycans of the envelope of HIV. Copyright © 2009, American Society for Microbiology. All Rights Reserved.-
dc.language.isoeng-
dc.publisherAmerican Society for Microbiology-
dc.rightsclosedAccess-
dc.titleThe phthalocyanine prototype derivative Alcian blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential-
dc.typeartículo-
dc.identifier.doi10.1128/AAC.00811-09-
dc.date.updated2013-09-17T09:13:01Z-
dc.description.versionPeer Reviewed-
dc.identifier.pmid19721061-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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