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http://hdl.handle.net/10261/82154
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | François, K. O. | - |
dc.contributor.author | Pannecouque, C. | - |
dc.contributor.author | Auwerx, Johan | - |
dc.contributor.author | Lozano, Virginia | - |
dc.contributor.author | Peréz-Pérez, María-Jesús | - |
dc.contributor.author | Schols, Dominique | - |
dc.contributor.author | Balzarini, Jan | - |
dc.date.issued | 2009 | - |
dc.identifier | doi: 10.1128/AAC.00811-09 | - |
dc.identifier | issn: 0066-4804 | - |
dc.identifier | e-issn: 1098-6596 | - |
dc.identifier.citation | Antimicrobial Agents and Chemotherapy 53: 4852- 4859 (2009) | - |
dc.identifier.uri | http://hdl.handle.net/10261/82154 | - |
dc.description.abstract | Alcian Blue (AB), a phthalocyanine derivative, is able to prevent infection by a wide spectrum of human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus strains in various cell types [T cells, (co)receptor-transfected cells, and peripheral blood mononuclear cells]. With the exception of herpes simplex virus, AB is inactive against a broad variety of other (DNA and RNA) viruses. Time-of-addition studies show that AB prevents HIV-1 infection at the virus entry stage, exactly at the same time as carbohydrate-binding agents do. AB also efficiently prevents fusion between persistently HIV-1-infected HUT-78 cells and uninfected (CD4+) lymphocytes, DC-SIGN-directed HIV-1 capture, and subsequent transmission to uninfected (CD4+) T lymphocytes. Prolonged passaging of HIV-1 at dose-escalating concentrations of AB resulted in the selection of mutant virus strains in which several N-glycans of the HIV-1 gp120 envelope were deleted and in which positively charged amino acid mutations in both gp120 and gp41 appeared. A mutant virus strain in which four N-glycans were deleted showed a 10-fold decrease in sensitivity to the inhibitory effect of AB. These data suggest that AB is likely endowed with carbohydrate-binding properties and can be considered an important lead compound in the development of novel synthetic nonpeptidic antiviral drugs targeting the glycans of the envelope of HIV. Copyright © 2009, American Society for Microbiology. All Rights Reserved. | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Microbiology | - |
dc.rights | closedAccess | - |
dc.title | The phthalocyanine prototype derivative Alcian blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1128/AAC.00811-09 | - |
dc.date.updated | 2013-09-17T09:13:01Z | - |
dc.description.version | Peer Reviewed | - |
dc.identifier.pmid | 19721061 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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