English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/81965
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
DC FieldValueLanguage
dc.contributor.authorReverón, Inés-
dc.contributor.authorRivas, Blanca de las-
dc.contributor.authorMuñoz, Rosario-
dc.contributor.authorLópez de Felipe, Félix-
dc.date.accessioned2013-09-13T06:45:50Z-
dc.date.available2013-09-13T06:45:50Z-
dc.date.issued2012-
dc.identifierissn: 1613-4125-
dc.identifier.citationMolecular Nutrition and Food Research 56: 1848-1859 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/81965-
dc.description.abstractScope: To advance knowledge of the stress tolerance mechanisms of a probiotic Lactobacillus plantarum strain to dietary hydroxycinnamic acids and the role of gut commensal microorganisms in the bioactivation of polyphenols. Methods and results: To understand how gut commensal microorganisms tolerate toxicity of hydroxycinnamic acids and bioactivate these compounds, we used whole genome transcriptional profiling to characterize the response of a L. plantarum human isolate during challenge with p-coumaric acid (p-CA). The transcriptional profile reveals a massive induction of genes involved in stress resistance and detoxification-related functions and a global shutdown of growth-associated processes. A specific oxidative stress response, including a large reshape of nitrogen metabolism toward methionine production, was induced, probably to counteract a p-CA-induced oxidative protein stress. The transcriptional datasets revealed overlapping behaviors with the response of L. plantarum to the gut environment. Conclusion: Contact with p-CA triggers responses that would be potentially beneficial for the intestinal function such as detoxification of dietary hydroxycinnamic acids and induction of a marked antioxidant response. Elicited responses indicated that contact with p-CA could provide preparedness to L. plantarum for adaptation to the gut environment. This knowledge facilitates the way to design methods to improve probiotic cell survival in this habitat. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.description.sponsorshipThis work was supported by grants AGL2008–01052, AGL2011–22745, and Consolider INGENIO 2010 CSD2007–00063 FUN-C-FOOD (CICYT), and S2009/AGR-1469 (ALIBIRD) (CAM).-
dc.language.isoeng-
dc.publisherWiley-VCH-
dc.relationS2009/AGR-1469/ALIBIRD-
dc.rightsclosedAccess-
dc.titleGenome-wide transcriptomic responses of a human isolate of Lactobacillus plantarum exposed to p-coumaric acid stress-
dc.typeartículo-
dc.identifier.doi10.1002/mnfr.201200384-
dc.relation.publisherversionhttp://dx.doi.org/10.1002/mnfr.201200384-
dc.date.updated2013-09-13T06:45:50Z-
dc.description.versionPeer Reviewed-
dc.contributor.funderComisión Interministerial de Ciencia y Tecnología, CICYT (España)-
dc.contributor.funderComunidad de Madrid-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100007273es_ES
Appears in Collections:(ICTAN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.