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dc.contributor.authorReverón, Inés-
dc.contributor.authorRivas, Blanca de las-
dc.contributor.authorMuñoz, Rosario-
dc.contributor.authorLópez de Felipe, Félix-
dc.identifierissn: 1613-4125-
dc.identifier.citationMolecular Nutrition and Food Research 56: 1848-1859 (2012)-
dc.description.abstractScope: To advance knowledge of the stress tolerance mechanisms of a probiotic Lactobacillus plantarum strain to dietary hydroxycinnamic acids and the role of gut commensal microorganisms in the bioactivation of polyphenols. Methods and results: To understand how gut commensal microorganisms tolerate toxicity of hydroxycinnamic acids and bioactivate these compounds, we used whole genome transcriptional profiling to characterize the response of a L. plantarum human isolate during challenge with p-coumaric acid (p-CA). The transcriptional profile reveals a massive induction of genes involved in stress resistance and detoxification-related functions and a global shutdown of growth-associated processes. A specific oxidative stress response, including a large reshape of nitrogen metabolism toward methionine production, was induced, probably to counteract a p-CA-induced oxidative protein stress. The transcriptional datasets revealed overlapping behaviors with the response of L. plantarum to the gut environment. Conclusion: Contact with p-CA triggers responses that would be potentially beneficial for the intestinal function such as detoxification of dietary hydroxycinnamic acids and induction of a marked antioxidant response. Elicited responses indicated that contact with p-CA could provide preparedness to L. plantarum for adaptation to the gut environment. This knowledge facilitates the way to design methods to improve probiotic cell survival in this habitat. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.description.sponsorshipThis work was supported by grants AGL2008–01052, AGL2011–22745, and Consolider INGENIO 2010 CSD2007–00063 FUN-C-FOOD (CICYT), and S2009/AGR-1469 (ALIBIRD) (CAM).-
dc.titleGenome-wide transcriptomic responses of a human isolate of Lactobacillus plantarum exposed to p-coumaric acid stress-
dc.description.versionPeer Reviewed-
dc.contributor.funderComisión Interministerial de Ciencia y Tecnología, CICYT (España)-
dc.contributor.funderComunidad de Madrid-
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