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Title

Iodine supplementation during pregnancy: a public health challenge

AuthorsBerbel, Pere; Obregón, María Jesús; Bernal, Juan ; Escobar del Rey, Francisco; Morreale de Escobar, Gabriella
Issue Date2007
PublisherElsevier
CitationTrends in Endocrinology and Metabolism 18(9): 338-343 (2007)
AbstractIodine deficiency remains the most frequent cause worldwide, after starvation, of preventable mental retardation in children. It causes maternal hypothyroxinemia, which affects pregnant women even in apparently iodine-sufficient areas, and often goes unnoticed because L-thyroxine (T4) levels remain within the normal range, and thyroid-stimulating hormone (TSH) is not increased. Even a mild hypothyroxinemia during pregnancy increases the risk of neurodevelopmental abnormalities, and experimental data clearly demonstrate that it damages the cortical cytoarchitecture of the fetal brain. The American Thyroid Association (ATA) recommends a supplement of 150 μg iodine/day during pregnancy and lactation, in addition to the use of iodized salt. We discuss the importance of iodine supplementation to ensure adequate T4 levels in all women who are considering conception and throughout pregnancy and lactation. © 2007 Elsevier Ltd. All rights reserved.
URIhttp://hdl.handle.net/10261/81818
DOI10.1016/j.tem.2007.08.009
Identifiersdoi: 10.1016/j.tem.2007.08.009
issn: 1043-2760
e-issn: 1879-3061
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