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dc.contributor.authorBelinchón, Mónica M.-
dc.contributor.authorGancedo, Juana M.-
dc.identifierdoi: 10.1111/j.1567-1364.2006.00136.x-
dc.identifierissn: 1567-1356-
dc.identifiere-issn: 1567-1364-
dc.identifier.citationFEMS Yeast Research 7(1): 40-47 (2007)-
dc.description.abstractThe glucose sensors Gpr1, Snf3 and Rgt2 generate the earliest signals produced by glucose in yeast. We showed that a lack of Gpr1 or Snf3/Rgt2 decreased by twofold the glucose induction of SUC2, but had no effect on the induction of pyruvate decarboxylase (Pdc). The induction of HXT1 was not affected by the absence of Gpr1. In an hxk1 hxk2 glk1 strain, high glucose fully induced SUC2, caused partial induction of HXT1 and had no effect on Pdc. In this strain, SUC2 induction was dependent on Gpr1, but HXT1 induction was not. Hxk2, required for the high expression of HXT1, was dispensable for the full induction of SUC2 or Pdc. These results indicate that glucose does not induce transcription through a single signalling pathway, but that several pathways may, in different combinations, regulate the transcription of different genes. © 2006 Federation of European Microbiological Societies.-
dc.description.sponsorshipThis work was supported by grants BMC2001-1690-C02-1 and BFU2004-02855-C02-1 from the Dirección General de Investigación Científica y Técnica (DGICYT) and by the European Union (EU) project BIO-HUG QLK3-CT-1999-00080. M.M.B. was supported by fellowships from the EU and the DGICYT.-
dc.titleDifferent signalling pathways mediate glucose induction of SUC2, HXT1 and pyruvate decarboxylase in yeast-
dc.description.versionPeer Reviewed-
dc.contributor.funderDirección General de Investigación Científica y Técnica, DGICT (España)-
dc.contributor.funderEuropean Commission-
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