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Title

1,2-mannobioside mimic: Synthesis, DC-SIGN interaction by NMR and docking, and antiviral activity

AuthorsReina, José J. ; Sattin, Sara; Invernizzi, Donatella; Mari, Silvia; Martinez-Prats, Lorena; Tabarini, Georges; Fieschi, Franck; Delgado, R.; Nieto, Pedro M. ; Rojo, Javier ; Bernardi, Anna
Issue Date2007
PublisherWiley-VCH
CitationChemMedChem 2: 1030- 1036 (2007)
AbstractThe design and preparation of carbohydrate ligands for DC-SIGN is a topic of high interest because of the role played by this C-type lectin in immunity and infection processes. The low chemical stability of carbohydrates against enzymatic hydrolysis by glycosylases has stimulated the search for new alternatives more stable in vivo. Herein, we present a good alternative for a DC-SIGN ligand based on a mannobioside mimic with a higher enzymatic stability than the corresponding disaccharide. NMR and docking studies have been performed to study the interaction of this mimic with DC-SIGN in solution demonstrating that this pseudomannobioside is a good ligand for this lectin. In vitro studies using an infection model with Ebola pseudotyped virus demonstrates that this compound presents an antiviral activity even better than the corresponding disaccharide and could be an interesting ligand to prepare multivalent systems with higher affinities for DC-SIGN with potential biomedical applications. © 2007 Wiley-VCH Verlag GmbH& Co. KGaA.
URIhttp://hdl.handle.net/10261/81656
DOI10.1002/cmdc.200700047
Identifiersdoi: 10.1002/cmdc.200700047
issn: 1860-7179
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