English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/81637
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Telomerase deficiency and cancer susceptibility syndromes

AuthorsPerona Abellón, Rosario ; Machado-Pinilla, R. ; Manguan-García, Cristina ; Carrillo, Jaime
Issue Date2009
PublisherSpringer
CitationClinical and Translational Oncology 11(11): 711-714 (2009)
AbstractTelomeres from most eukaryotes are composed of repeats of guanine-rich sequences whose main function is to preserve the end of the chromosomes. Telomeres are synthesised by a reverse transcriptase enzyme, telomerase (TERT), which forms part of a ribonucleoprotein complex containing also a RNA template molecule (TERC) and dyskerin. Exhaustion of telomeres during cell divisions triggers a DNA damage response that induces a senescence phenotype. The DNA damage machinery plays an essential role in maintaining the integrity of the genome and also detecting telomere shortening. However in some syndromes that involved mutations either in the telomerase complex genes or those involved in maintaining DNA secondary structure, such as the recQ helicase WRN, a higher frequency in the development of different types of malignancies is observed. We here describe the biology of some of these diseases, together with the molecular modifications in the telomerase complex genes and the impact of these alterations on the development of particular types of cancer. © 2009 Feseo.
URIhttp://hdl.handle.net/10261/81637
DOI10.1007/s12094-009-0432-9
Identifiersdoi: 10.1007/s12094-009-0432-9
issn: 1699-048X
e-issn: 1699-3055
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.