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Título: | Intratumoral lymphatic vessels and VEGF-C expression are predictive factors for lymph node relapse in T1-T4 N0 laryngopharyngeal squamous cell carcinoma |
Autor: | Hinojar-Gutiérrez, Adolfo; Fernández-Contreras, María Encarnación; Quintanilla, Miguel CSIC ORCID; Gamallo, Carlos | Fecha de publicación: | 2007 | Editor: | Springer Nature | Citación: | Annals of Surgical Oncology 14(1): 248-257 (2007) | Resumen: | [Background]: The presence of intratumoral lymphatic vessels (ILVs) and the expression of vascular endothelial growth factor-C (VEGF-C) in tumour cells have been studied as markers of lymphangiogenesis in order to evaluate their role in metastatic dissemination in laryngopharyngeal squamous cell carcinoma. [Methods]: A retrospective study was performed in 76 patients of N0 laryngopharyngeal carcinoma. with variable tumour size (T1-T4), histological grade, and location (supraglottic, glottic and hypopharyngeal). The presence of ILVs, as revealed by the expression of PA2.26 antigen and VEGF-C expression, were determined by immunohistochemistry (IHC). Low-grade and high-grade lymphangiogenesis were defined by qualitative and quantitative criteria. [Results]: Multivariate analysis revealed low-grade ILV and VEGF-C expression to be associated respectively with 30.3- and 16.2-fold higher probabilities of cervical lymph node relapse (P = 0.005 and P = 0.032) and with 16.2- and 8.44-fold shorter disease-free survival (P = 0.009 and P = 0.045). [Conclusions]: Low-grade ILV and VEGF-C expression are independent predictive factors of cervical lymph node relapse and shortening of time to relapse in N0 laryngopharyngeal carcinoma. | URI: | http://hdl.handle.net/10261/81576 | DOI: | 10.1245/s10434-006-9201-y | Identificadores: | doi: 10.1245/s10434-006-9201-y issn: 1068-9265 e-issn: 1534-4681 |
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