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A convenient and efficient synthesis of the first (nitroimidazolyl)succinic esters and their diacids

AuthorsPacheco-Torres, Jesús; Pérez-Mayoral, Elena; Soriano, Elena ; López-Larrubia, Pilar ; Ouari, Olivier; Cerdán, Sebastián ; Ballesteros, Paloma
Issue Date2006
CitationSynthesis 22: 3859-3864 (2006)
AbstractWe report an easy and efficient synthetic approach to the first series of (nitroimidazolyl)succinic esters and diacids involving the Michael-type addition of the nitroimidazole to the α,β-unsaturated ester. Voltammetric measurements revealed similar redox potentials to those of previous nitroimidazoles used in hypoxia detection. Theoretical calculations were implemented to understand the mechanism of the addition. © Georg Thieme Verlag Stuttgart.
Identifiersdoi: 10.1055/s-2006-950320
issn: 0039-7881
e-issn: 1437-210X
Appears in Collections:(IIBM) Artículos
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