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From theoretical calculations to the enantioselective synthesis of a 1,3,4-trisubstituted Gly-derived 2-azetidinone

AuthorsPérez-Faginas, Paula CSIC; Alkorta, Ibon CSIC ORCID; García-López, M. Teresa CSIC; González-Muñiz, Rosario CSIC ORCID
Issue Date2008
CitationTetrahedron Letters 49: 215- 218 (2008)
AbstractTheoretical calculations on the transition states of the cyclization of 2S-chloropropionyl amino acid derivatives to the corresponding β-lactams have served to explain the high stereoselectivity of the reaction, and have been the driving force to extend the procedure to the preparation of a Gly-derived 1,3,4-trisubstituted 2-azetidinone in enantiopure form. © 2007 Elsevier Ltd. All rights reserved.
Identifiersdoi: 10.1016/j.tetlet.2007.11.099
issn: 0040-4039
Appears in Collections:(IQM) Artículos
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