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E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations

AuthorsPeña, Cristina; García, José M.; Silva, Javier; García, Vanesa; García de Herreros, Antonio; Muñoz Terol, Alberto ; Bonilla, Félix
Issue Date2005
PublisherOxford University Press
CitationHuman Molecular Genetics 14(22): 3361-3370 (2005)
AbstractE-cadherin (CDH1) gene expression is strictly regulated. The trabscriptional factors SNAIL and ZEB1 are involved in its repression, whereas activation of vitamin D receptor (VDR) by vitamin D induces its transcription. We study the expression and functional correlation of SNAIL, CDH1, VDR and ZEB1genes and examine their possible involvement in colon cancer. The expression of these four genes was measured by real time-PCR in 114 patients with colorectal cancer, and tumor characteristics were analyzed in each patient. SNAIL expression was associated with downregulation of CDH1 (P<0.001) and VDR (P<0.001) gene products. We also found a positive correlation between CDH1and VDR expressions. However, the association between SNAIL and CDH1 was not found in patients with high expression of ZEB1. We observed a correlation between downregulation of: a) ZEB1 and presence of polyps in surgical resections; b) VDR and poor differentiation and c) CDH1 and poor differentiation, vascular invasion, presence of lymph node metastases and advanced stages; as well as a trend toward a correlation between SNAIL expression in tumors and vascular invasion. The correlations between SNAIL, CDH1, VDR and ZEB1 and the association between reduced expression of CDH1 and VDR and aggressive tumor characteristics emphasize the value of analyzing these genes in colon cancer patients for prognostic purposes and for predicting response to possible therapies with vitamin D or its analogs. © The Author 2005. Published by Oxford University Press. All rights reserved.
Identifiersdoi: 10.1093/hmg/ddi366
issn: 0964-6906
e-issn: 1460-2083
Appears in Collections:(IIBM) Artículos
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