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dc.contributor.author | Llosa, Matxalen | - |
dc.contributor.author | Roy, Craig | - |
dc.contributor.author | Dehio, Christoph | - |
dc.date.accessioned | 2013-08-29T10:35:32Z | - |
dc.date.available | 2013-08-29T10:35:32Z | - |
dc.date.issued | 2009 | - |
dc.identifier | doi: 10.1111/j.1365-2958.2009.06751.x | - |
dc.identifier | e-issn: 1365-2958 | - |
dc.identifier | issn: 0950-382X | - |
dc.identifier.citation | Molecular Microbiology 73(2): 141-151 (2009) | - |
dc.identifier.uri | http://hdl.handle.net/10261/81119 | - |
dc.description | El pdf del artículo es el manuscrito de autor: PMCID: PMC2784931 | - |
dc.description.abstract | Summary Type IV secretion (T4S) systems are versatile machines involved in many processes relevant to bacterial virulence, such as horizontal DNA transfer and effector translocation into human cells. A recent workshop organized by the International University of Andalousia in Baeza, Spain, covered most aspects of bacterial T4S relevant to human disease, ranging from the structural and mechanistic analysis of the T4S systems to the physiological roles of the translocated effector proteins in subverting cellular functions in infected humans. This review reports the highlights from this workshop, which include the first visualization of a T4S system core complex spanning both membranes of Gram-negative bacteria, the identification of the first host receptors for T4S systems, the identification and characterization of novel T4S effector proteins, the analysis of the molecular function of effector proteins in subverting human cellular functions and an analysis of the role of T4S systems in the evolution of pathogenic bacteria. Our increasing knowledge of the biology of T4S systems improves our ability to exploit them as biotechnological tools or to use them as novel targets for a new generation of antimicrobials. © 2009 Blackwell Publishing Ltd. | - |
dc.description.sponsorship | This workshop was organized by the UNIA (Spain) and supported by the UNIA, the Instituto de Salud Carlos III (Spanish Ministry of Health), and the University of Cantabria (Spain). Research in our labs is funded by Grants BIO2008-00133 from the Spanish Ministry of Science of Innovation and API 07/01 from Public Foundation Marqués de Valdecilla (to M. L.), NIH Grants AI041699 and AI064559 (to C. R.) and Grant 3100A0-109925/2 form the Swiss National Science Foundation and Grant 55005501 from the Howard Hughes Medical Institute (to C. D.). | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons | - |
dc.rights | openAccess | - |
dc.title | Bacterial type IV secretion systems in human disease | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/j.1365-2958.2009.06751.x | - |
dc.relation.publisherversion | http://dx.doi.org/10.1111/j.1365-2958.2009.06751.x | - |
dc.date.updated | 2013-08-29T10:35:32Z | - |
dc.description.version | Peer Reviewed | - |
dc.identifier.pmid | 19508287 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Fichero | Descripción | Tamaño | Formato | |
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Bacterial type IV.pdf | 199,23 kB | Adobe PDF | Visualizar/Abrir |
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