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Title

One-pot cascade reactions using fructose-6-phosphate aldolase: Efficient synthesis of D-arabinose 5-phosphate, D-fructose 6-phosphate and analogues

AuthorsSánchez-Moreno, Israel ; Hélaine, Virgil; Poupard, N.; Charmantray, Franck; Légeret, B.; Hecquet, Laurence; García-Junceda, Eduardo ; Wohlgemuth, R.; Guérard-Hélaine, Christine; Lemaire, Marielle
Issue Date2012
PublisherJohn Wiley & Sons
CitationAdvanced Synthesis and Catalysis 354: 1725- 1730 (2012)
AbstractOne-pot multienzymatic reactions have been performed for the synthesis of 1-deoxy-D-fructose 6-phosphate, 1,2-dideoxy-D-arabino-hept-3-ulose 7-phosphate, D-fructose 6-phosphate and D-arabinose 5-phosphate. The whole synthetic strategy is based on an aldol addition reaction catalysed by fructose-6-phosphate aldolase (FSA) as a key step of a three or four enzymes-catalysed cascade reaction. The four known donors for FSA - dihydroxyacetone (DHA), hydroxyacetone (HA), 1-hydroxy-2-butanone (HB) and glycolaldehyde (GA) - were used with D-glyceraldehyde 3-phosphate as acceptor substrate. The target phosphorylated sugars were obtained in good to excellent yields and high purity. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URIhttp://hdl.handle.net/10261/81053
DOI10.1002/adsc.201200150
Identifiersdoi: 10.1002/adsc.201200150
issn: 1615-4150
e-issn: 1615-4169
Appears in Collections:(IQOG) Artículos
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