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Integrative expression system for delivery of antibody fragments by lactobacilli

AuthorsMartín, M. Cruz ; Pant, Neha; Ladero Losada, Víctor Manuel ; Günaydın, Gökçe; Krogh Andersen, Kasper; Álvarez, Beatriz; Martínez Álvarez, Noelia ; Álvarez González, Miguel Ángel ; Hammarström, Lennart; Marcotte, Harold
Issue Date2011
PublisherAmerican Society for Microbiology
CitationApplied and Environmental Microbiology 77(8): 2174-2179 (2011)
AbstractA series of expression cassettes which mediate secretion or surface display of antibody fragments was stably integrated in the chromosome of Lactobacillus paracasei. L. paracasei producing surface-anchored variable domain of llama heavy chain (VHH) (ARP1) directed against rotavirus showed efficient binding to rotavirus and protection in the mouse model of rotavirus infection. © 2011, American Society for Microbiology.
Identifiersdoi: 10.1128/AEM.02690-10
issn: 0099-2240
e-issn: 1098-5336
Appears in Collections:(IPLA) Artículos
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