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Título: | Discovering novel bile protection systems in Bifidobacterium breve UCC2003 through functional genomics |
Autor: | Ruíz García, Lorena CSIC ORCID ; Zomer, Aldert; O'Connell-Motherway, Mary; Sinderen, Douwe van; Margolles Barros, Abelardo CSIC ORCID | Fecha de publicación: | abr-2012 | Editor: | American Society for Microbiology | Citación: | Applied and Environmental Microbiology 78(4): 1123-1131 (2012) | Resumen: | Tolerance of gut commensals to bile salt exposure is an important feature for their survival in and colonization of the intestinal environment. A transcriptomic approach was employed to study the response of Bifidobacterium breve UCC2003 to bile, allowing the identification of a number of bile-induced genes with a range of predicted functions. The potential roles of a selection of these bile-inducible genes in bile protection were analyzed following heterologous expression in Lactococcus lactis. Genes encoding three transport systems belonging to the major facilitator superfamily (MFS), Bbr_0838, Bbr_0832, and Bbr_1756, and three ABC-type transporters, Bbr_0406-0407, Bbr_1804-1805, and Bbr_1826-1827, were thus investigated and shown to provide enhanced resistance and survival to bile exposure. This work significantly improves our understanding as to how bifidobacteria respond to and survive bile exposure. © 2012, American Society for Microbiology. | URI: | http://hdl.handle.net/10261/80793 | DOI: | 10.1128/AEM.06060-11 | Identificadores: | doi: 10.1128/AEM.06060-11 issn: 0099-2240 e-issn: 1098-5336 |
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