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Función del gen lines y la fmailia odd-skipped en la integración de múltiples vías de señalización durante el desarrollo del ala de drosophila

AuthorsBenítez, Elvira
AdvisorGuerrero Vega, Isabel ; Rodríguez Enríquez, Isabel
Issue Date2008
PublisherUniversidad Autónoma de Madrid
AbstractThis thesis aim to investigate the lines function during the imaginal wing disc development. It was found that lines mutant cells induce an aberrant responses to key signaling pathways: Notch (N), Wingless (Wg), JAK/STAT, Decapentaplegic (Dpp) and EGFR, which yield changes in the proximal-distal cell identity and a cell dramatic overgrowth. A regulatory network involving Lines/Drumstick/Bowl is implicated in the integration of patterning information at several stages during the development. It was shown that the same cassette is important in integrating several different signaling events in the developing wing. Moreover, two additional members of the odd-skipped family were included to this regulatory network, odd and sob. Drm, Odd and Sob inhibit Lines functions allowing Bowl nuclear accumulation. Drm controls nuclear Lines levels, Lines turns down the steady-state accumulation of Bowl protein in the wing disc. Odd and Sob fail in Lines relocalization to the cytoplasm but their ability to interact with Bowl suggests that the formation of a protein complex would inhibit Lines function. Genetic experiments show that Bowl is the primary effector of this regulatory network. In this generic network Drm/Lines/Bowl, lines is implicated in the wing development by limiting Bowl expression to the peripodial cells. A genetic interaction between Lines/Bowl and Groucho, a general co-repressor of N, Wg, EGFR, and Dpp pathways it was found. It is proposed that Lines is a modular factor of transcriptional complexes that integrates the response to different signaling pathways to control patterning and growth during development.
DescriptionTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología Molecular. Fecha de lectura 29-02-2008
Appears in Collections:(CBM) Tesis
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