English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/80334
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Activation of MAPKs by G protein-coupled receptors.

AuthorsCrespo, Piero ; Gutkind, J. Silvio
Issue Date2004
PublisherHumana Press
CitationMAP Kinase Signaling Protocols IV (Cap. 14): 203-210 (2004)
SeriesMethods in Molecular Biology 250
AbstractG protein-coupled receptors (GPCRs) constitute the largest family of cell-surface molecules involved in signal transmission. These receptors play key physiologic roles, with their dysfunction resulting in a number of disease states (1). Recently, we have learned that many of the cellular responses mediated by GPCRs do not involve the sole stimulation of conventional second-messenger-generating systems, but result from the functional integration of an intricate network of intracellular signaling pathways. Among these, the main mitogenactivated protein kinase (MAPK) pathways, those mediated by extracellular signal-regulated kinase (ERK)1-2, c-Jun N-terminal kinase (JNK), p38, and ERK5/big mitogen-activated protein kinase (BMK), are potently activated by GPCRs (2). GPCRs owe their name to their extensively studied interaction with heterotrimeric G proteins (α-, β-, and γ-subunits), which undergo conformational changes that lead to the exchange of guanosine 5′-diphosphate for guanosine 5′-triphosphate (GTP) bound to the α-subunit on receptor activation. Consequently, Gα- and Gβγ-subunits stimulate effector molecules, including adenylyl and guanylyl cyclases, phosphodiesterases, phospholipase A2 (PLA2) and PLC, and phosphatidylinositol-3 kinases, thereby activating or inhibiting the production of a variety of second messengers, such as cyclic adenosine monophosphate, cyclic guanosine monophosphate, diacylglycerol, inositol triphosphate (IP3), and phosphatidyinositol triphosphate (PIP3), arachidonic and phosphatidic acid, and promoting (Ca2+) elevation and the opening or closing of a variety of ion channels (3).
URIhttp://hdl.handle.net/10261/80334
DOIhttp://dx.doi.org/10.1385/1-59259-671-1:203
Identifiersdoi: 10.1385/1-59259-671-1:203
isbn: 978-0-89603-998-8
Appears in Collections:(IIBM) Libros y partes de libros
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.