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dc.contributor.author | Jiménez-Mateos, Eva María | - |
dc.contributor.author | González-Billault, Christian | - |
dc.contributor.author | Dawson, Hana N. | - |
dc.contributor.author | Vitek, Michael P. | - |
dc.contributor.author | Ávila, Jesús | - |
dc.date.accessioned | 2008-10-27T15:57:27Z | - |
dc.date.available | 2008-10-27T15:57:27Z | - |
dc.date.issued | 2006-03-15 | - |
dc.identifier.citation | Biochemical Journal 397(1): 53–59 (2006) | en_US |
dc.identifier.issn | 0264-6021 | - |
dc.identifier.uri | http://hdl.handle.net/10261/8024 | - |
dc.description.abstract | The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures. An additional role for MAPs has emerged recently where they appear to participate in the regulation of transport of cargos on the microtubules found in axons. In this role, tau has been associated with the regulation of anterograde axonal transport. We now report that MAP1B is associated with the regulation of retrograde axonal transport of mitochondria. This finding potentially provides precise control of axonal transport by MAPs at several levels: controlling the anterograde or retrograde direction of transport depending on the type of MAP involved, controlling the speed of transport and controlling the stability of the microtubule tracks upon which transport occurs | en_US |
dc.description.sponsorship | This work is supported by PNCYT (Plan Nacional de Ciencia y Tecnología), CM (Comunidad de Madrid) and FIS (Fondo de Investigación Sanitaria) grants to J.A., and by NIH (National Institutes of Health) grant AG 15307 to M.P.V. We thank Dr J. J. Lucas for critical reading and correction of this manuscript before submission. E.M.J.-M. was awarded with a fellowship from Spanish MCYT (Ministerio de Ciencia y Tecnología). | en_US |
dc.format.extent | 514884 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Biochemical Society | en_US |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | en_US |
dc.subject | Axonal transport | en_US |
dc.subject | Bidirectional movement | en_US |
dc.subject | Microtubule | en_US |
dc.subject | Microtubule-associated protein 1B (MAP1B) | en_US |
dc.subject | Mitochondrion | en_US |
dc.subject | Tau | en_US |
dc.title | Role of MAP1B in axonal retrograde transport of mitochondria | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1042/BJ20060205 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1042/BJ20060205 | en_US |
dc.identifier.e-issn | 1470-8728 | - |
dc.contributor.funder | Ministerio de Ciencia y Tecnología (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Instituto de Salud Carlos III | - |
dc.contributor.funder | National Institutes of Health (US) | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100006280 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100000002 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.pmid | 16536727 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
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EMJimémez-Mateos_BiochemJ_53.pdf | 502,82 kB | Adobe PDF | Visualizar/Abrir |
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