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dc.contributor.authorJiménez-Mateos, Eva María-
dc.contributor.authorGonzález-Billault, Christian-
dc.contributor.authorDawson, Hana N.-
dc.contributor.authorVitek, Michael P.-
dc.contributor.authorÁvila, Jesús-
dc.date.accessioned2008-10-27T15:57:27Z-
dc.date.available2008-10-27T15:57:27Z-
dc.date.issued2006-03-15-
dc.identifier.citationBiochemical Journal 397(1): 53–59 (2006)en_US
dc.identifier.issn0264-6021-
dc.identifier.urihttp://hdl.handle.net/10261/8024-
dc.description.abstractThe MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures. An additional role for MAPs has emerged recently where they appear to participate in the regulation of transport of cargos on the microtubules found in axons. In this role, tau has been associated with the regulation of anterograde axonal transport. We now report that MAP1B is associated with the regulation of retrograde axonal transport of mitochondria. This finding potentially provides precise control of axonal transport by MAPs at several levels: controlling the anterograde or retrograde direction of transport depending on the type of MAP involved, controlling the speed of transport and controlling the stability of the microtubule tracks upon which transport occursen_US
dc.description.sponsorshipThis work is supported by PNCYT (Plan Nacional de Ciencia y Tecnología), CM (Comunidad de Madrid) and FIS (Fondo de Investigación Sanitaria) grants to J.A., and by NIH (National Institutes of Health) grant AG 15307 to M.P.V. We thank Dr J. J. Lucas for critical reading and correction of this manuscript before submission. E.M.J.-M. was awarded with a fellowship from Spanish MCYT (Ministerio de Ciencia y Tecnología).en_US
dc.format.extent514884 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherBiochemical Societyen_US
dc.relation.isversionofPublisher's version-
dc.rightsopenAccessen_US
dc.subjectAxonal transporten_US
dc.subjectBidirectional movementen_US
dc.subjectMicrotubuleen_US
dc.subjectMicrotubule-associated protein 1B (MAP1B)en_US
dc.subjectMitochondrionen_US
dc.subjectTauen_US
dc.titleRole of MAP1B in axonal retrograde transport of mitochondriaen_US
dc.typeartículoen_US
dc.identifier.doi10.1042/BJ20060205-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1042/BJ20060205en_US
dc.identifier.e-issn1470-8728-
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderNational Institutes of Health (US)-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100006280es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100012818es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.pmid16536727-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
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