Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/79896
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Epigenetics of Host-Pathogen Interactions: The Road Ahead and the Road Behind |
Autor: | Gómez-Díaz, Elena CSIC ORCID; Jordá, Mireia; Peinado, Miguel A.; Rivero Lynch, Ana CSIC ORCID | Fecha de publicación: | 29-nov-2012 | Editor: | Public Library of Science | Citación: | PLoS Pathogens 8(11): e1003007 (2012) | Resumen: | A growing body of evidence points towards epigenetic mechanisms being responsible for a wide range of biological phenomena, from the plasticity of plant growth and development to the nutritional control of caste determination in honeybees and the etiology of human disease (e.g., cancer). With the (partial) elucidation of the molecular basis of epigenetic variation and the heritability of certain of these changes, the field of evolutionary epigenetics is flourishing. Despite this, the role of epigenetics in shaping host-pathogen interactions has received comparatively little attention. Yet there is plenty of evidence supporting the implication of epigenetic mechanisms in the modulation of the biological interaction between hosts and pathogens. The phenotypic plasticity of many key parasite life-history traits appears to be under epigenetic control. Moreover, pathogen-induced effects in host phenotype may have transgenerational consequences, and the bases of these changes and their heritability probably have an epigenetic component. The significance of epigenetic modifications may, however, go beyond providing a mechanistic basis for host and pathogen plasticity. Epigenetic epidemiology has recently emerged as a promising area for future research on infectious diseases. In addition, the incorporation of epigenetic inheritance and epigenetic plasticity mechanisms to evolutionary models and empirical studies of host-pathogen interactions will provide new insights into the evolution and coevolution of these associations. Here, we review the evidence available for the role epigenetics on host-pathogen interactions, and the utility and versatility of the epigenetic technologies available that can be cross-applied to host-pathogen studies. We conclude with recommendations and directions for future research on the burgeoning field of epigenetics as applied to host-pathogen interactions. © 2012 Gómez-Díaz et al. | Versión del editor: | http://dx.doi.org/10.1371/journal.ppat.1003007 | URI: | http://hdl.handle.net/10261/79896 | DOI: | 10.1371/journal.ppat.1003007 | Identificadores: | doi: 10.1371/journal.ppat.1003007 issn: 1553-7366 e-issn: 1553-7374 |
Aparece en las colecciones: | (IBE) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
epigenetics_ host_pathogen_Gomez.pdf | 822,65 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
92
checked on 02-abr-2024
SCOPUSTM
Citations
192
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
172
checked on 27-feb-2024
Page view(s)
376
checked on 24-abr-2024
Download(s)
341
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.