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Title

Greater diversity than previously thought of chromaffin cell Ca2+ channels, derived from mRNA identification studies

AuthorsGarcía-Palomero, Esther; Renart, Jaime CSIC ORCID; Montiel, Carmen
Issue Date2000
PublisherElsevier
CitationFEBS Letters 481(3): 235-239 (2000)
AbstractUsing reverse transcription followed by PCR amplification (RT-PCR), we have identified multiple messenger RNAs encoding for the neuronal pore- forming Ca2+ channel subunits α(1A) (P/Q channel), α(1B) (N channel), α(1D) (neuronal/endocrine L channel), α(1E) (R channel), α(1G-H) (T channel) and α(1S) (skeletal muscle L channel) in bovine chromaffin cells. mRNAs for the auxiliary β2, β3, β4, α2/δ and γ2 subunits were also identified. In agreement with these molecular data, perforated patch-clamp recordings of whole-cell Ca2+ currents reveal the existence of functional R-type Ca2+ channels in these cells that were previously undetected with other techniques. Our results provide a molecular frame for a much wider functional diversity of Ca2+ channels in chromaffin cells than that previously established using pharmacological and electrophysiological approaches. (C) 2000 Federation of European Biochemical Societies.
URIhttp://hdl.handle.net/10261/79712
DOI10.1016/S0014-5793(00)01984-0
Identifiersdoi: 10.1016/S0014-5793(00)01984-0
issn: 0014-5793
e-issn: 1873-3468
Appears in Collections:(IIBM) Artículos

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